Chemoselective calcium-catalysed direct amidation of carboxylic esters
نویسندگان
چکیده
منابع مشابه
Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.
Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via tra...
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Esters are one of the most common functional groups in natural and synthetic products, and the one-step conversion of the ester group into other functional groups is an attractive strategy in organic synthesis. Direct amidation of esters is particularly appealing due to the omnipresence of the amide moiety in biomolecules, fine chemicals, and drug candidates. However, efficient methods for dire...
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Centre for Sustainable Chemical Process University, Science Site, South Road, Durha durham.ac.uk Department of Chemistry, University Coll WC1H 0AJ, UK Department of Chemistry, Durham Univer DH1 3LE, UK Department of Chemistry, Imperial Colle London, SW7 2AZ, UK † Electronic supplementary information spectra, computational data and ES 1551614–1551624 and 1563948–1563950. CIF or other electronic ...
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Iron triflate, in situ-formed from FeCl3 and triflic acid, or FeCl3 and silver triflate efficiently catalyse the intermolecular addition of carboxylic acids to various alkenes to yield carboxylic esters; the reaction is applicable to the synthesis of unstable esters, such as acrylates.
متن کاملPractical copper(I)-catalysed amidation of aldehydes.
The direct synthesis of amides by insertion into the C-H bond of aldehydes is shown to be a practical procedure through application of cheap, readily available catalysts generated in situ from copper(i) halides and pyridine.
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2015
ISSN: 2046-2069
DOI: 10.1039/c5ra18288c